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Top FDA Official Says Triple-Vaccinated Americans Eligible for 4th COVID-19 Shot Will Likely Need a 5th Dose This Fall

Dr. Peter Marks, head of the FDA office responsible for vaccine safety, indicated this week that the U.S. might need to offer fourth shots for people under 50-years-old in the fall.

People who are now eligible for fourth shots would likely get a fifth shot if there’s evidence that would be beneficial, Marks told reporters on a conference call.

Marks also said the U.S. could switch to a different COVID-19 vaccine that targets a specific variant of SARS-CoV-2 or a mix of several. The current COVID-19 vaccines were developed against the original Wuhan virus.

Pfizer and Moderna are conducting clinical trials on COVID-19 booster shots that target both Omicron and other circulating variants of SARS-CoV-2.

“It would not be surprising if there is a potential need for people to get an additional booster in the fall along with a more general booster campaign if that takes place,” Marks said. “It may be that a decision is made that rather than the vaccines we currently have, which are called vaccines against the prototype virus, that we will move to a vaccine that is either against one of the variants or something else.”

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